Brain Development A Human Right ,

By Amy Price PhD

Clicking on Train Your Brain , Save Your Mind here will take you to a fascinating short video on the power of personal brain optimization and contains a clinically validated assessment tool. This video is presented by Dr Evian Gordon of Brain Resource Company and speaks to the highly acclaimed wellness program, My Brain Solutions. It is well worth investigating, in less than 15 days I showed improvement on several measures of cognition. If you would like to sign-up for MyBrainSolutions please email me ….read on for why training your brain matters… If you have difficulty signing up or have questions please post a comment and I will be happy to help you with this.

Research on cognition that shows transfer of training and increase in quality of life is dependent on carefully assessing individual differences with  clinically accepted tools which provide personalized training to meet these perimeters[1,2,3,4,]


Learning and novelty are partners yet many brain fitness programs offer rote repetition of weak areas without variation in task or content in a bid to target learning, However research shows us this is not the way meaningful learning occurs. Tasks must be individually challenging to hold engagement and yet structured enough to be doable. Ideally tasks will adapt to changing learning curves to build neuroplasticity. The best learning capitalizes on emotional and intellectual strengths already present while strengthening areas of weakness in a positive atmosphere. For example, teaching a university student mnemonics and concept mapping may make the memory more efficient however teaching an individual with organic damage or early dementia how to remember names and faces with a mnemonic is an exercise in futility.

Specific training alone can lead to plastic changes in the brain as demonstrated by expert Braille readers who show an enlarged hand area and smearing of finger representations in the somatosensory cortex. This result was observed in expert, but not in novice Braille readers suggesting that the training and not the blindness which leads to the changes in cortical representation [5]Similar domain specific results were noted in London taxi drivers and expert violinists. Kramer et al [6] states recruitment of additional brain regions helps performance only if the recruited area complements processing of the task in question. This is likely why rote memorization fails to increase working memory whereas training that targets attentional networks and processing speed increases working memory limits. We are incapable of processing in depth what we have not attended to and our capacity for material attended to is limited by the speed at which we process stimuli.

My Brain Solutions has an inviting Dashboard where you can  Empower Your Own Life....See you at the Dashboard!

1. Posner, M., & Rothbart M. Educating the human brain. Washington, DC US: American Psychological Association.; 2007:189-208. doi:10.1037/11519-009


2. Jaeggi SM, Buschkuehl M, Jonides J, Perrig WJ. Improving fluid intelligence with training on working memory. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(19):6829-33. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18443283

3. Willis SL, Tennstedt SL, Marsiske M, et al. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA : the journal of the American Medical Association. 2006;296(23):2805-14. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17179457


4. Gordon E, Arns M, Paul RH. Research Report THE INTEGRATE MODEL OF EMOTION, THINKING AND SELF REGULATION: AN APPLICATION TO THE “PARADOX OF AGING”. Thinking. 2008;7(3):367-404.

5. Greenwood PM. Functional plasticity in cognitive aging: review and hypothesis. Neuropsychology. 2007;21(6):657-73. http://www.ncbi.nlm.nih.gov/pubmed/17983277


6. Kramer AF, Bherer L, Colcombe SJ, Dong W, Greenough WT. Environmental influences on cognitive and brain plasticity during aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 2004;59(9):M940-57.: http://www.ncbi.nlm.nih.gov/pubmed/15472160.

Does Platelet Rich Plasma Really Work?

By Amy Price PhD

What is Platelet Rich Plasma Treatment (PRP)?


PRP has been around since the 1980s but mostly as an adjunct to surgical or dental procedures. PRP patients have a small amount of their own blood removed and then processed through a centrifuge machine. The high speed rotation separates red blood cells from the platelets. A teaspoon or two of the clear platelet rich concentrate (3 to 10 times that of regular blood) will be returned and injected into damaged areas to catalyze the growth of new cells.

Various methods are now commercially available for preparing PRP and a similar material called “autologous growth factor,” which is PRP plus the white blood cell buffy coat obtained during PRP preparation. As a result, assessment of these strategies in clinical orthopedic practice has accelerated.

The platelet rich mixture can be injected where the area does not normally have a rich blood supply and has the advantage of not triggering a clotting response. Patients are their own donors so there is little risk of rejection, allergy or transmissable infections Some stem cell companies are combining PRP with stem cell therapy to increase healing results. The theory and technique behind PRP is similar to that of Prolotherapy (proliferation therapy). Typically Prolotherapy treatments are offered first, and mostly resolve musculoskeletal problems. When results from traditional Prolotherapy treatments are not adequate, PRP may be employed. PRP and Prolotherapy, are office procedures.

How does PRP therapy help?

The body’s responds to injury by mobilizing platelet cells. Platelets are packed with multiple healing and growth factors which initiate repair while attracting stem cells the bodies built in construction managers. PRP intensifies the body’s healing efforts by delivering concentrated platelets. The technique appears to help regenerate ligament and tendon fibers, which shortens rehabilitation time.

How long will it take?

One to two hours, including preparation and recovery time is the average time for the procedure. Advantages include pain relief and speedy healing without the risk of surgery, Many individuals can return to work right after the procedure.

How often can a person have PRP done?

The norm is three injections within a six-month time frame, two to three weeks apart. Relief is usually recognized after the first or second injection.

What are the expected results?

Initial improvement may be seen within a few weeks, gradually increasing as the healing progresses. Some doctors describe PRP as a growth factor cocktail. MRI images after PRP have shown definitive tissue repair. It seems to work better on soft tissue areas like tendons and ligaments, in bone injury it may even slow healing. Results are donor dependent and certain health conditions such as diabetes, thyroid disease or habits like smoking and heavy drinking may hinder the effectiveness as can hormone deficiencies. Younger patients and athletes have more growth factors resident in platelets so this makes them better overall candidates Research into the effects of platelet-rich plasma therapy has accelerated in recent months, with most doctors cautioning that more rigorous studies are necessary before the therapy can emerge as scientifically proven. Even with a 20-40% failure rate many researchers suspect that the procedure could grow in attractiveness treatment for reasons both medical and financial. PRP is about 2000.00 dollars, stem cell therapy is about 8000.00 per site plus travel, diagnostics, preparation and time whereas surgery is much more expensive with extensive recuperation time. PRP has also been used to augment surgery with promising results.

References

1. Rai B, Oest ME, Dupont KM, Ho KH, Teoh SH, Guldberg RE: Combination of platelet-rich plasma with polycaprolactone-tricalcium phosphate scaffolds for segmental bone defect repair. J Biomed Mater Res A 2007;81:888-899.

2. Sipe JB, Zhang J, Waits C, Skikne B, Garimella R, Anderson HC: Localization of bone morphogenetic proteins (BMPs)-2, -4, and -6 within megakaryocytes and platelets. Bone 2004;35:1316-1322.

3. Kark LR, Karp JM, Davies JE: Platelet releasate increases the proliferation and migration of bone marrow-derived cells cultured under osteogenic conditions. Clin Oral Implants Res 2006;17:321-327.

4. Gruber R, Kandler B, Fischer MB, Watzek G: Osteogenic differentiation induced by bone morphogenetic proteins can be suppressed by platelet-released supernatant in vitro. Clin Oral Implants Res 2006;17:188-193.

5. Ranly DM, McMillan J, Krause WF, Lohmann CH, Boyan BD, Schwartz Z: Platelet-rich plasma: A review of its components and use in bone repair, in Akay M (ed): Encyclopedia of Biomedical Engineering, vol 5. Hoboken, NJ: John Wiley & Sons, Inc., 2006, pp 2804-2815.

6. Ranly DM, Lohmann CH, Andreacchio D, Boyan BD, Schwartz Z. Platelet-rich plasma inhibits demineralized bone matrix-induced bone formation in nude mice. J Bone Joint Surg Am 2007;89:139-147.

7. Schwartz Z, Somers A, Mellonig JT, et al: Ability of commercial demineralized bone allograft to induce bone formation is donor age-dependent but not gender-dependent (abstract). Trans Orthopaed Res Soc 1997;22:230.

8. Weibrich G, Kleis WK, Hitzler WE, Hafner G. Comparison of the platelet concentrate collection system with the plasma-rich-in-growth-factors kit to produce platelet-rich plasma: A technical report. Int J Oral Maxillofac Implants 2005;20:118-123.

9. Thibault L, Beausejour A, de Grandmont MJ, Lemieux R, Leblanc JF: Characterization of blood components prepared from whole-blood donations after a 24-hour hold with the platelet-rich plasma method. Transfusion 2006;46:1292-1299.

10. Li H, Zou X, Xue Q, Egund N, Lind M, Bunger C: Anterior lumbar interbody fusion with carbon fiber cage loaded with bioceramics and platelet-rich plasma: An experimental study on pigs. Eur Spine J 2004;13:354-358.

11. Weiner BK, Walker M: Efficacy of autologous growth factors in lumbar intertransverse fusions. Spine 2003;28:1968-1970.

12. Muschler GF, Nitto H, Matsukura Y, et al: Spine fusion using cell matrix composites enriched in bone marrow-derived cells. Clin Orthop Relat Res 2003;(407):102-118.

13. Muschler GF, Matsukura Y, Nitto H, et al: Selective retention of bone marrow-derived cells to enhance spinal fusion. Clin Orthop Relat Res 2005;(432):242-251.

14. Brodke D, Pedrozo HA, Kapur TA, et al: Bone grafts prepared with selective cell retention technology heal canine segmental defects as effectively as autograft. J Orthop Res 2006;24:857-866.

15. Murray MM, Spindler KP, Ballard P, Welch TP, Zurakowski D, Nanney LB: Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res 2007;25:1007-1017.

Keep Todays Memories For Tomorrow-Free Screenings

Sparks of Genius Brain Optimization Center to Hold Free Memory Screenings

National Event Stresses the Importance of Proper Detection and Treatment

Boca Raton, FL— Consumers who want a status check on their memory can take advantage of free, confidential screenings on November 17 as part of National Memory Screening Day, an annual initiative of the Alzheimer’s Foundation of America (AFA) designed to promote proper detection of memory problems and strategies for successful aging.
Memory screenings are a significant first step toward finding out if a person may have a memory problem. Memory problems could be caused by Alzheimer’s disease or other medical conditions.
Now in its seventh year, AFA’s National Memory Screening Day coincides with National Alzheimer’s Disease Awareness Month, which takes place during November.
On November 17, Sparks of Genius Brain Optimization Center will hold memory screenings at 7777 Glades Road, Boca Raton, from 10 am – 3 pm. Please call 561-859-4060 for more information or to make an appointment. You are also welcome to stop by. Refreshments will be provided.
At Sparks of Genius we offer cognitive training program which can slow down the progression of memory loss or delay it’s onset.
AFA suggests memory screenings for adults concerned about memory loss or experiencing warning signs of dementia; whose family and friends have noticed changes in them; or who believe they are at risk due to a family history of Alzheimer's disease or a related illness. Screenings also are appropriate for those who do not have a concern right now, but who want to see how their memory is now and for future comparisons.
The event features a face-to-face screening, which takes only about five to ten minutes, and consists of a series of questions and tasks. Screenings will be conducted by Dr. Rohn Kessler, Dr. Amy Price and Ninah Kessler, LCSW. The results do not represent a diagnosis, and AFA advises those individuals with below-normal scores or those who have normal scores but are still concerned to follow up with a qualified healthcare professional.
Eric J. Hall, AFA’s president and CEO, is urging consumers “to be proactive about brain health.”
”We pay so much attention to the health of our bodies, but we should be equally concerned about the health of our brains,” he said. “National Memory Screening Day offers the opportunity to find out how your memory is now and to learn how to protect it in the future.”

For more information about National Memory Screening Day, visit www.nationalmemoryscreening.org or call 866-AFA-8484.

Telomeres, Telomerase and The Graduate Student

By Amy Price PhD
Carol Greider was still a graduate student when she started work on a project that along with Elizabeth Blackburn and Jack Szostak  won this year's Nobel prize for medicine. These US-based researchers  discovered how the body protects the chromosomes housing vital genetic code.

Genetics intrigue me because they are beautifully ordered and I have wondered and asked how the telomeres and telemorase are sequenced. When the telemeres are shortened life span is reduced whereas if there is uncontrolled growth cell corruption occurs. These scientists did more than ask they worked together to find answers.

Elizabeth Blackburn, of the University of California, San Francisco, and Jack Szostak, of Harvard Medical School, discovered that a unique DNA sequence in the telomeres protects the chromosomes from degradation.


Joined by Johns Hopkins University's Carol Greider, then a graduate student, Blackburn started to investigate how the teleomeres themselves were made and the pair went on to discover telomerase - the enzyme that enables DNA polymerases to copy the entire length of the chromosome without missing the very end portion.

Some inherited diseases are now known to be caused by telomerase defects, including certain forms of anaemia in which there is insufficient cell divisions in the stem cells of the bone marrow. Apparently elevated telomerase can be a biological marker for malignancy and there is research underway to see if vaccines can be developed to arrest the defects.

The Nobel Assembly at Sweden's Karolinska Institute, which awarded the prize, said: "The discoveries... have added a new dimension to our understanding of the cell, shed light on disease mechanisms, and stimulated the development of potential new therapies."

Disease and Genomic Advances

By Amy Price PhD

Until recently only a geneticist Francis Crick and one other individual have had their genome read. Apparently Dr Crick did not wish to know if he had a specific dominant gene for dementia but was happy to know all other variants. No one knows the public impact in the face of fullscale  genetic information and there are ethical concerns as genetic engineering has not enjoyed a widespread safety or success rate but it appears the tide may be shifting.

A 5 month old male baby from Turkey was critically ill. Scientists and doctors teamed together from multiple nations to enable the reading of  his genome quickly and were able to work out that he had a wrong diagnosis. This was reported in 'Proceedings of the National Academy of Sciences'. The analysis only took ten days and determined that the boy suffered a genetic mutation that coded for a gut disease that eventually destroys other organs including the kidneys. Additional clinical tests determined that the boy had the rare disease and he is now recovering.

The boy's physician sent a blood sample and Dr Lifton of Yale Medical school along with teams in Beirut and Turkey decoded the DNA to reveal a diagnosis. The scientists did a follow up study with 39 patients who had the same condition the boy was originally thought to have and found that five them had the same genetic mutation. For practical reasons, the initial concentration is on the small percentage of the genome which codes for proteins rather than the non coding DNA.

Rather than the usual method of  looking one gene at a time hoping to guess which was the right gene causing the problems,  a new method was utilized where they could look at all the genes in the genome simultaneously.  They identified a specific allele which had mutations on both copies and which causes the sufferers not to be able to absorb water or electrolytes through the gastrointestinal tract.

This is a turning point in personalized predictive medicine. Professor Mike McCarthy, a geneticist at Oxford University commented, "This is an interesting study - lots of groups are now using the power of new methods for sequencing the human genome to find DNA changes that underlie rare diseases (and increasingly for common diseases too)".

There is tremendous potential for Genomics to pave the way for diagnostic breakthroughs.

Brain Optimization For The Job You Want!

By Ninah Kessler, Brain Fitness Coach

Can an economic downturn be good? Can it help you to recreate your life at a higher level? It can if you have the right mindset. That’s why it’s so important to teach your brain to think positively. But we also have to take care of the machinery of the brain itself. We need brain fitness.

The experts used to think that we all had a limited number of neurons in our brain. Then in the 1990’s, the decade of the brain, neuroscientists discovered that we could develop new neurons and new neuronal connections at any age. If we want to succeed in this new millennium, it behooves us to strengthen our brains.

Without help, our brains reach their peak in our twenties and then start deteriorating. By our 40’s we can usually notice a difference. It’s really very similar to what happens to our bodies. On the cognitive level, names disappear and our brains slow down. Multitasking becomes more challenging. The technical term for this is age related cognitive decline. It’s normal, but it’s not nice.

The good news is that there are things that we can do to slow down and reverse this process.

I’d like to give you an analogy from the physical world. In the 2008 Summer Olympics Dara Torres beat out women half her age to bring home silver medals. How did she do that? It wasn’t luck or chance. She created a professional training team to supercharge her body. On the everyday level, if you want to create a functional aesthetically pleasing body, you have a better chance if you work with a professional trainer or at least take a class. If you are extremely motivated, you can create your own program, but most of us do not have this level of commitment.

The key to training our brains is to expose ourselves to new and novel stimulation, continually challenging ourselves to take it to a higher level. Now we can all do this on our own to a certain degree. Crossword puzzles and suduko are good, and Nintendo DS, bridge, golf and bananagrams are even better. Traveling is great, especially if you learn a language, and playing a new musical instrument is a great neuronal enhancer. And don’t forget to eat a healthy diet, get physical exercise and decrease stress.

But the experience is enhanced with the expertise of a brain fitness coach. It is brain science to know that there are many different abilities that need training – logic, memory, attention, processing speed and mental flexibility, to name a few. Creating a training program that compensates for your weaknesses and enhances your strengths is an art.

When you’re looking for a job, you need your brain to be at its best. You need mental flexibility to figure out where the jobs are and how to format your old job qualifications into skills sets that will take you where you want to be. You need auditory processing ability and processing speed to answer questions in an interview. The best way to get these skills is with a brain fitness coach. You can even increase your brain fitness even if you’re dyslexic, have adult ADHD or a brain injury. Those with cognitive challenges often benefit the most.

A brain fitness coach can help you with stress too. It’s so easy for our thoughts to take a negative direction especially when we are looking for a job. Do you really have the luxury of wasting long periods of time in an unnecessary funk?

At Sparks of Genius, we’ve been training people to get the most out of their brains since 2001 and we have been cited as a brain fitness leader in The Wall Street Journal. You can work with your own personalized fitness coach or be part of a group. One day brain fitness coaches will be as popular as life coaches or personal trainers. But for you, that day can be now.

Ninah Kessler, LCSW, Brain Fitness Coach. SparksofGenius.com 561-859-4060

TBI and Hypothyroid Connection

Thyroid problems may make you fat and moody
By Amy Price PhD

People who have sustained head or serious neck injuries can also damage the thyroid as well. Sometimes people who are diagnosed with whiplash later develop thyroid issues. Many of the symptoms of hypothyroid are the same as those as those for people who have dealt with a brain injury so they tend to be ignored. This is tragic because low thyroid levels can eventually lead to cognitive damage and even dementia. The thyroid can be damaged even if you are thin. It is not always true that people gain massive amounts of weight with this kind of condition just as it is not true that people with a past brain injury need to be constantly exhausted or depressed. The video above will tell you about symptoms and what you can do about this disorder

Your thyroid gland weighs less than an ounce and is located in the front of your neck just below the Adam’s apple. The thyroid acts as a feedback mechanism for your metabolism so when it is too slow or too fast this can upset a lot of body functions The thyroid gland takes iodine and converts it into thyroid hormones. Thyroid cells are the only cells in the body which can absorb iodine. These cells combine iodine and the amino acid tyrosine to make T3 and T4. T3 and T4 are then released into the blood stream and are transported throughout the body where they control metabolism (conversion of oxygen and calories to energy). Every cell in the body depends upon thyroid hormones for regulation of their metabolism.

Get this checked by your doctor. It takes a simple blood test and oral medication. This disorder can show up years after an injury so be aware.


Symptoms of a slow thryroid include

•Fatigue, Depression

•Weight gain or increased difficulty losing weight, or loss of appetite

•Coarse, dry hair, thinning hair or outer portion of eybrows thinning out

•Dry, rough pale skin,

•Cold and heat intolerance  (you can't tolerate cold temperatures like those around you)

•Muscle cramps and frequent muscle aches, weakness

•Constipation

•Depression, Irritability

•Memory loss, lack of focus, reduced coordination

•Abnormal menstrual cycles, decreased interest in sex

Hip Replacement Alternative

By Amy Price PhD
My husband underwent adult stem cell therapy in hopes of staving off hip replacement. The technique in the USA was in the early stages and his hip degeneration was acute. In the end he underwent bilateral hip resurfacing in the UK. The procedure was successful and gave him his life back. The UK surgeons were most interested in stem cell therapy and they were working on getting stem cells federally funded particularly for revision surgery which happens when the artificial hip wears out after about fifteen years.

It was exciting to learn about six hip patients who underwent a very creative stem cell procedure in Spire Hospital, Southhampton UK. This procedure could prevent thousands of people from needing to have an artificial hip fitted.

Here is a short breakdown on how they are doing this. Surgeons are using the patient’s own stem cells to rejuvenate the affected bone and donor bone to speed the process. The stem cells are extracted from the patient’s pelvis, purified and cultured in an organic mixture that promotes growth. When the cells had multiplied they were mixed with cleaned, ground-up hip bone from other patients who had hips replaced.Surgeon then excised dead tissue from the ball of the hip and filled the cavity with the mixture of stem cells and donated bone.

Professor Richard Oreffo of Southampton University explains that stem cells send out chemical signals to attract blood vessels. "Bone is a living vibrant tissue. These stem cells generate new tissue and drive new blood vessel formation to bring in nutrients," he said.

Dr Dunlop is hopeful that this therapy will fix the hip for life. Early reports look promising with good results in 5 out of 6 study participants. The television footage on this was stunning. One patient who had his procedure a year ago looked like he had never experienced a hip problem.
Scientists and doctors are working together to expand this study and to explore the viability of using artificial bone. This would eliminate the problem of donor generated deficits being passed on although I suspect those already in need of new body parts are happy to take their chances.

This news is hot on the heels of research by scientists in New Jersey USA who have successfully isolated nerve growth factors in mesynchemal stem cells and grown them out as published in the latest issue of the Journal of Neurochemisty. Cell biology and Genetic engineering advances may soon provide real answers for those with untreatable neurodegenerative conditions and even those who have sustained brain injury.
Scientist and doctor teams are now considering how this therapy could be applied to other degenerative conditions.

Predictive Medicine

By Amy Price PhD

Predictive medicine can change our tomorrows today. Regenerative medicine can replace artificial body parts with lab grown technologies while genetic breakthroughs can save families from generations of genetic disability. It is possible that new knowledge of human genetics and cell biology is likely to transform medical practice. Three likely scenarios could evolve:

•Genetics will lead to the classification of diseases on the basis of the underlying genetics or biochemistry, rather than by symptoms alone leading to preventive rather than crisis orientated treatments.
•Genetic information will identify people who are likely to respond to drugs, or to be harmed by them (pharmacogenetics). This is already possible with certain psychotropic drugs on an experimental level but has not trickled down into mainstream medicine.
•Genetic variation will be a new ‘susceptibility factor’, permitting monitoring and early treatment or, perhaps prevention, of an increasing proportion of common, multifactorial diseases, such as coronary heart disease, hypertension, stroke, cancer, diabetes and Alzheimer's disease. Even stress management can be amplified with knowledge of individual genotypes

It is the genetic variation susceptibility factor which is considered to be the change maker for the advent of predictive medicine. This could lead to regenerative medicine on a cellular (somatic) level or even in vitro gene manipulation (germ line therapy) which could prevent intergenerational transfer of genetic disabilities.
Predictive medicine, when it comes, will be based on a much wider use of genetic testing, at present the gap between what the healthcare system is geared up and trained to deliver and what is scientifically viable is huge. For example there are treatments approved for traumatic brain injury that are effective but most be given within a couple of hours of trauma. This can’t happen now because emergency room personnel are not adequately trained or equipped to diagnose MTBI... As with any new technology applied to health in the context of a complex delivery system, implementation is not going to be simple.

First, of course, there needs to be demand from medical personnel and the general public. Typically wide spread change will only take place after the following criteria are established:

•Demonstration of clinical effectiveness and patient safety – through statistically valid clinical trials
•Cost-effective for general use – through economic analysis of trials and other data;
•Standardization of technology, and quality control – generally through outside regulation of suppliers and laboratories;
•Allocation of resources;
•Recruitment and education and training (or retraining) for health workers – including specialists, MDs, nurses, counselors and technicians. For instance a surgeon who makes a good living performing spinal fusions and cervical repairs will need significant convincing, retraining and motivation to become an early adopter of treatment that makes the previous way of doing business obsolete.

Predictive, regenerative medicine may be the wave of the future. History teaches us that the way to greatness is to find a way to serve many. My dream is to witness a generation of scientists and medical professionals join in unity with a foundation of integrity to build a tomorrow for the patients and public who have make their careers possible.

References:

Materials adapted from Open University Course Materials (accessed july,2009)

I Need Stem Cells!

By Amy Price PhD

Adult stem cell viability is on many minds. I have had queries from UN ambassadors to children of only nine asking me about stem cells. The curiousity is international but the questions are the same. People are not sure who to trust and they need stem cells now. Many can not travel to other countries because they are too ill and others lack funding for private stem cell clinics. Some of these feel the FDA or the NHS is unreasonable in thier demands for testing while others feel patient testimonials should be outlawed. My own training is in mental health/psychology so patient to patient information is all I can offer.

I personally like patient testimonials especially when they are accompanied by forums where people discuss how and if the treatment worked and what the hurdles were in getting treatment. I have often learned more from groups of patients with an experience than from professionals with just a theory. Forums are not meant to be professional research, they are peer to peer information only. Google stem cell or regenerative medicine forums and you will get many choices.

I agree clinical trials and time are important to assess treatments but realistically it will be 15 or 20 years before long term results are on the table for clinical trials. There are some companies that have obtained FDA approval for trials, others are listed at clinicaltrials.gov It may be useful to look at this Doctor's description of FDA off label drug use for drugs to understand how the rules were set up and to get an inkling of how this could all translate to cell biology.

My concerns are that engineering any living object is not a simple process and what looks simple from the outside in a needle in/needle out sort of process is very complex from a laboratory perspective and all the answers may not be in. Some clinics are reputable, give good patient care and patients are reporting good long-term results. Some patients are fortunate enough to get into a university sponsored trial that is tied to a major research hospital. Other clinics are still using methods that were proven ineffective many years ago. Patients are vulnerable and need protection sometimes even from themselves. I can no longer count the number of friends I have lost to questionable therapies after spending family fortunes in a quest for a cure. There are no easy answers...

Having said this and knowing from personal experience the agony of chronic unrelenting pain and the sadness of life lost because of disability I would not likely wait until the votes were in but would join in the age old clamor of patients trapped by pain "Just fix me!" The International Society for Stem Cell Research has released guidelines which are helpful to use when considering any new therapy. The PDF is available here

Instant stem cells...Freeze Dried Anyone?

By Amy Price PhD

I recently shared some posts on umbilical cord banking information. Dr Fran Verter of the Parent’s Guide to Cord Blood Foundation shared with us how this works. It seems storage and transport can introduce complications so I wondered what would happen if we eliminated those high tech freezers and freeze dried the stem cells instead. Could they be reconstituted and retain the integrity needed to reproduce?

I located a journal article on Plos One along with others who are using these techniques. Apparently the first generation reproduced DNA accurately which is no surprise as this is a forensics basics but the other portions of the cell needed for healthy growth didn't survive. They are now getting success rates in the 90% range for cells they have reconstituted and then reproduced. The University of Rochester, Image above, is showing some interesting research on using freeze dried cells for bone repair and tissue engineering

This solves a lot of storage problems, should reduce costs and cells could last for years. The ones used in the studies were three years old and over. It is anyone's guess how long this could take to become a viable option for human adult stemcell storage but what a great concept...Stemcells To Go

The Spinal Injury Blues!

By Amy Price PhD

With spinal injuries and head injuries it is often the secondary damage to the neurons that causes big problems especially when that swelling and inflammation is in the spinal cord or the brain. The worst damage shows up several hours to many days later. Now, scientists in Rochester, New York, have discovered a simple way to stop a lot of this secondary damage in its tracks...at least in mice by using that old familiar blue food dye that gives M&Ms, blue bubble gum and blue raspberry popsicles their color. Patients with spinal injuries could escape with vastly reduced loss of function if this works in people but they'll turn bright blue in the process.

Much secondary damage is caused by adenosine triphosphate, or ATP. This chemical can go into overkill with trauma and cause neurons to fire until they burn out and die leaving inflammation and sludge to trip up the neurons behind them causing an unhealthy destructive cycle. With spinal trauma, the area around the injury is flooded with ATP, which causes otherwise healthy neurons to fire out of control until they die of exhaustion. It also increases the swelling around the wound. Swelling around an injury site is a positive healing factor in many parts of the body, but because the spinal cord is encased in a narrow column blood supply gets cut off and cells die. But a study published in July 28's Proceedings of the National Academy of Sciences (PNAS) seems to show that it's possible to block the actions of ATP and greatly reduce the severity and permanence of spinal injuries - using the same type of food dye that gives blue M&Ms their color, a food dye called Brilliant Blue G, or BBG.

BBG can be administered intravenously with no need to inject directly into the injury site. It has the ability to cross the blood-brain barrier, which then gives it access to the spinal cord. BBG binds to the same neuroreceptor (P2X7) as the ATP binds to but it has a stronger affinity for the receptor than ATP has and gets there first so it effectively blocks the action of the ATP at the injury site.
Only one problem....patients turn blue ! It is temporary and is sure better than having a serious injury. You wear the injury but the blue die wears off.....All I can say is color me blue for spinal injury.

See the full method of the experiments here (PDF). BBG has been a food dye approved by the FDA since the 1920s but would this be considered off label use like the cholesterol lowering of Cheerios cereal. While all the rats were severely injured, the BBG-injected rats showed a greatly improved ability to support their bodyweight on their hind legs, control their bladders, and even walk in some cases. The blue skin coloring eventually faded as well, and no side effects were noted.

Human testing would be required before BBG can be moved forward into clinical use. It would be a terrific tool for ambulance drivers and paramedics. They could begin treatment right at the site of the incident, It is cheap and easy, even hospitals can use the blue stuff as soon as they get the patient hooked up and ready to go.

The kids must have known best when they told me blue ice cream was good for me ...As for me...I will stock up on blue Gatorade and drink it down just in case it could make a difference!

Scar Care Hints and Tips

By Amy Price PhD

Scar care can make a difference in how you heal. In Europe and Canada scar aftercare is taught following an injury or surgery. It is important that the scar is allowed to heal shut before any attempt is made to cover it with silicone or massage it.

Your doctor is the best one to advise you about the best time to start. If the scar becomes hot, oozes, or bleeds a lot get medical attention. If the area turns black, is extremely painful or very dark, smells,or has dark lines leading way from the wound get it checked by a doctor. Remember some emergency rooms have as high as a 30%return visit ratio so being seen in emergency does not necessarily mean all is well.

If dissolving stitches were used to repair the wound follow your doctors advice for care. The surgeon who repaired my hand and wrist suggested using antibiotic ointment with Zinc oxide until the wound healed and using hand sanitizer for the areas that contained pins. I was urged not to get it wet because the pins go into the bone and infection can become systemic if bacteria is allowed to enter.

Once the wound has healed gentle massage using cream, vitamin E, olive oil, evening primrose oil will keep the area lubricated and help soften it. I was advised to use small circular motions in both directions to break up adhesions and to promote circulation. Gentle but firm consistent pressure is needed. Getting over enthusiastic can re-injure tissue and cause inflammation.

Silicone pads cut to the wound size are very effective in taking away redness,and to reduce raised scars. It does take a few weeks to show results so be patient. The silicone pads can be bought as washable reusable patches that last about a month or as disposable patches that you use and throw away.Best results come from leaving the patches on about 12 hours at a time. They should not be used on open wounds because of the risk of infection. First aid tape can be used to keep the scar sheet in place. Avoid getting it wet. If you are allergic to silicone there are polymer patches that work the same way.

Silicone gel is good to use on areas like knuckles, elbows or the face. It is very important to protect the scarred area from sun exposure for at least two years to avoid damage to skin.

If you are unfortunate enough to experience a road rash scar keep it covered and moist until the skin underneath heals. Burn dressings available at a pharmacy work quite well. Keep it clean with saline and antibiotic ointment rather than using hydrogen peroxide or other harsh disinfectants that will burn and damage the skin underneath. If it is a large area using a cut up tube sock over the dressing can protect it. Remember to keep the dressing and the area clean to promote healing.

Diet makes a difference this is a good time to eat fruits and vegetables plus sufficient protein. Fish oil, vitamin C and antioxidants will help to promote healing.

This Post is for educational patient to patient purposes only and is not meant to treat, diagnose or take the place of medical care or advice.

Diabetes Type 1 and 2 Adult Stemcell Trials Underway

By Amy Price PhD

The Journal of the American Medical Association, reported on a study of young adults with newly diagnosed diabetes. These young people were treated with their own stem cells. 20 out of 23 reduced or ended dependence on insulin as their bodies took over production of insulin. Twelve patients stayed off insulin for extended periods, while eight relapsed and returned to low-dose shots. Three didn’t respond. The average time individuals avoided insulin shots was 31 months

The concept driving the research is as follows. In type I diabetes, the patient’s immune system turns on the beta cells that produce insulin, the hormone that breaks down the glucose we eat in food. Eventually, the immune cells will virtually eliminate all of the body's beta cells, and glucose levels will start to climb. Researchers considered if they wiped out the original immune system and replaced it with stem cells it could reset the person’s immune system with disease free cells.
Patients are fist treated with chemotherapy to reduce overactive immune system. Stem cells extracted from the patient’s own blood are grown out and later returned through intravenous injection. This procedure is carried out within six weeks of initial diagnosis for best chance of recovery.

The procedure is certainly not risk free as complications of the stem-cell treatment included pneumonia in two patients, low sperm counts in nine of the 17 men in the study, and endocrine dysfunction in three patients.

Levels of C Peptide were measured as this substance shows up when cells are making insulin. 20 out of 23 participants showed improved insulin production.

Julio Voltarelli, and colleagues at the University of Sao Paulo, Brazil, with colleagues in the U.S. worked on this project. Voltarelli's team has managed to show that the stem cells can give long-lasting beta cells a chance to grow — at least ones that can produce insulin for about three years. Other researchers are pursuing intriguing new stem cell options, including stem cells that can be grown from a patient's own skin, which would eliminate the need for extracting immune stem cells from bone marrow.

No one considers this a cure yet but it is a step in the right direction “A cure is needed, but it will probably not come from a single breakthrough,” wrote Christopher D. Saudek of Johns Hopkins University in Baltimore, in an accompanying editorial. "I wouldn't use the word cure," says Dr. Richard Burt, one of the co-authors from Northwestern University. "But it appears we changed the natural history of the disease. It's the first therapy for patients that leaves them treatment-free — no insulin, no immune suppression for almost five years."
"Every door that we open leads to another door," says Burt. "All research is built by sitting on the shoulders of other studies. This trial is something that will contribute to and move the field of stem cell therapy forward." It is, as Burt says, a start. For a Julio Voltarelli and colleague webcast click here

A study using donor adult bone marrow stem cells has garnered FDA approval with a company called Osiris Approximately 60 patients will be enrolled in this trial. Male and female patients are eligible and must be between the ages of 18 and 30 years old. Patients must have been diagnosed with T1DM based on the ADA criteria and must be screened for clinical trial eligibility between 2 and 16 weeks from initial T1DM diagnosis.

If you or someone you know has recently been diagnosed with T1DM and you would like more information, please contact us at Diabetes@Osiris.com.

There is also a study underway as of March for type 2 Diabetes. The university of Miami in conjunction with other sites are starting clinical trials combining adult stem cell therapy with hyperbaric oxygen as this combination was quite promising in an initial pilot study. As of January 2009 Researchers were planning to recruit patients between the ages of 45 and 65 who have been diagnosed with type 2 diabetes after age 40 and have had the disease for more than five but less than 15 years. The media contact for this research is below. You can read more at http://www.diabetesresearch.org/Newsroom/NewsReleases/DRI/oxygenstemcells.htm
Media Contact:
Jeanne Krull
University of Miami Miller School of Medicine
305-243-4853 / 305-812-6668
jkrull@med.miami.edu

The image is borrowed from a blog with a really concise nicely done diabetes information site http://kirstyne.wordpress.com/2007/09/03/another-reason-to-keep-your-weight-in-check-diabetes/
More information can be found at http://www.diabetes.org/

Inflammation, Alzheimers, NSAIDS and Balance

Image from Harvard.edu

By Amy Price PhD

There is some information on the internet declaring Alzheimers is more common in people who take NSAIDS. I have watched people do things like take vicodin instead of an antiinflammatory or discontinue baby aspirin therapy suggested by a cardiologist to deal with sticky platelets. Some will not take an antiinflammatory because bone fractures don't heal as well if one is simultaneously taking this class of medication.

Getting drug addicted,setting up the CNS for chronic pain sensitivity by not treating inflammation,or letting excess platelet aggregation continue doesn't help cognition either and in may ultimately set you up for the very condition you are trying to avoid.

There is research reporting specific use of antiinflammatory agents may reduce Alzheimers. It could be chronic pain and inflammation that aggravate loss of cognition rather than the NSAIDS taken to alleviate the symptoms.

There are many cardiac patients who took part in a Canadian study 25 years ago. They were encouraged to take a baby aspirin, vitamin C, and calcium buffered with vitamins K and D rather than be placed on beta blockers and more heavy duty cardiac meds. For many of these individuals this regimen solved the problem.

Drug addiction doesn't always come from illegal street drugs. There are multitudes who became addicted just trying to stop the long term pain. These drugs work by altering nerve and brain messengers and overtime this leads to imbalance in the way the brain works.
As for the bones? Studies show that in eostrogen deficient or aged persons aspirin use may protect bone density. Research also shows fracture healing can be slowed by antiinflammatory use but this effect is temporary and if you stop taking them the fracture will heal at a normal rate.

In conclusion it is all about balance...

Save This Brain

By Amy Price PhD

There have been multiple articles featuring brain and serious neck injury stating how people have overcome cognitive obstacles despite adversity. I celebrate these articles as I know from personal experience the tolls that this road takes and the cost to family members and supporters. One mother was explaining how one minute her brain injured son could do complex algebra and the next he could not tell a red diamond from a black spade in a deck of cards. I too remember those days.

The cognitive inconsistencies are joined by emotional areas. Sometimes the brain will forget what we want it to remember and play over and over like a broken tape those areas we only want to put behind us. The other day I found some practical help in the way of videos and research on how to navigate the initial trauma. These outline what to expect in the emergency room, how to protect yourself in the event of a crash and ways you can help yourself get the best medical care. I thought I would share them here. If you go to the web site you can download the material as MP3 or as PDF files. This is a brilliant solution as watching a video makes it tough to pick up the references which are the key to deeper study...Enjoy!

In the next few posts there will be strategies for overcoming brain fog and getting the sharp mental edge back

Immediate Post Surgery Wound Care Hints

By Amy Price PhD

After surgery wound care could be better addressed. The advice is usually to ice the area for twenty minutes at a time and don't get it wet for 48 hours to 21 days depending on the procedure because of infection risks. Who are they kidding...After bleeding, being washed down with iodine and being touched,probed,cut and stitched by hands I have no personal relationship with all that I want is a bath or a shower!

The risk of infection is serious as it can travel to your bones or become systemic and cause more damage than the original problem. It can travel through open places in the wound or through the stitching which acts as a wick. Until the area has healed over it is best not to swim or use a hot tub because of bacterial risks. It is important to follow your doctor's advice for changing dressings etc. If the area becomes hot to the touch, swells rapidly,starts pulsing or you start to run a fever get your doctor's advice.

To shower after spine and cervical surgery I purchased a silicon swim cap as this is completely waterproof and less irritating than latex. I cut generous pieces which I placed over the wound and taped it in place with duct tape. For arms and legs I used umbrella bags, big ones for leg and smaller for arm areas. I placed them over top of the dressing and bandage and taped this in place. You will still need to exercise care and try not to get the area wet...a bath could be a bad idea! If it gets a little damp in spite of all precautions gently dry the area, put on topical antibiotic and replace the dressing.

If this was an emergency room visit remember emergency rooms will only stabilize you, they have no obligation to provide treatment beyond this. An emergency room visit needs follow up with a doctor. At emergency if you have tendons exposed insist on being seen by a specialist on call. I had three fingers all with tendon avulsions stitched up with no repairs. It took a year of occupational and physical therapy to get the function back. A word to the wise...if you have broken something and they have splinted, cast or wrapped it and it starts to smell bad or the exposed areas turn dark and lumpy go back to the hospital. They don't mean literally black, if it darkens substantially, swells and get worse rather than better have this checked out. With a temporary cast the swelling can cut off the circulation and the tissue starts to die. I almost lost a hand this way as I was told if it turns black come back, since it cost me 10,000 dollars for the emergency room appearance and 273 dollars for a bandage available at the dollar store.I really wasn't up for a repeat visit!

The ice is easy in principle but not so easy for the drugged and injured to apply. Some people travel for surgery and it is a considerable time before they are at home to ice. Do yourself a favor and buy some instant ice at a pharmacy before your procedure or get the surgery to supply you with a couple of extra packs for the trip home. The ice takes down swelling and eases pain while helping your body heal. At home consider the wound site. An awkward area like the elbow,knees or shoulders may be best with a bag of frozen peas which will bend to the shape. A posterior neck surgery may benefit from an emptied and refilled with water large soda bottle (don't freeze the soda it explodes). Ask a family member or friend to do ice duty day and night. If you are like me and don't want to ask anyone for anything consider that you can buy them a gift, take them to dinner or return the favor. It is an investment in your healing. Be nice to those who care enough to be available, they do not benefit from you getting an attitude because you feel bad that you need the help and being thankful can go along ways towards preserving relationships

There will be a follow up post on scar care soon. This information is for educational purposes only and does not constitute medical advice. That is your doctor's assignment.

Two Hearts, The FDA and Stem cells

By Amy Price PhD
My email informs me people are hungry for real help on finding medical providers who can offer stem cells. They want to know are stem cells a viable alternative, Can you find me quality information instead of hype, and what is your view on the FDA in this regard?

This field is moving very rapidly and what was not possible only a year ago is happeneing today.I have sen great and not so great results for orthopedic, heart, blood and some wound healing applications but it is important to realize that this therapy is still in experimental stages and there are no guarantees.

A few pioneers have moved through the opposition and fear of new therapies to pave the way for university hospitals who are now offering up stem cells in the way of research. One good example is new heart tissue grown out in Los Angeles "We seek to actually reverse the injury that has been caused by the heart attack, by re-growing new heart muscle to at least partially replace the scar that's formed," says Dr. Eduardo Marban of Cedars-Sinai Heart Institute

Watch CBS Videos Online
A tale of two hearts summarizes this nicely. Both hearts were damaged. The first heart was in a young man whose parents are dedicated medical professionals. They waited eagerly for FDA clearance so they could take their son for a legal stem cell repair. The wait was too long and emergency surgery ensued. The young man lived but sustained brain damage and paralysis. This heart could have been repaired with adult stem cells. A company that developed the stem cell technology was less than one hour from them. The cultural mindset opinion that procedures performed outside of North America because of FDA restrictions were too risky cost them deeply.

On the other spectrum was a banker friend well known in the diplomatic community? His heart was damaged and he was urged to change his lifestyle and lose weight. He picked up over the counter diet pills later banned by the FDA and marched to the treadmill like a soldier in boot camp to the acclaim of family and treating professionals. Noticing his lips and finger tips had an ominous bluish tinge, I asked to see the pills. They contained amphetamines in the form of herbs. We urged him to see his cardiologist and to stop the pills but he chose to soldier on until a month later he collapsed on the treadmill and was taken to hospital where his chest was sawed open and major heart surgery took place as it was the only way to save his life.
The FDA found a niche because when humans are physically vulnerable they will pay or do almost anything for survival. They keep us safe from predators in the marketplace. They help us with food labels and medical warnings. Dieters have been known to ingest tapeworms, destroy their stomachs, livers, kidneys, hearts and intestines to lose a few pounds. Doctors who see patients on whom they conduct treatment for a fee will say I have to be honest with you the chances aren’t great but if it is your choice we can proceed. They are applauded for their ‘honesty’ whether the treatment succeeds or not. We say go ahead because even false hope is better than none at all. Likely none of us would hire a roofer who said I will work on your roof but because of pre-existing structural damage it likely won’t work out! The FDA has a tough job and emotional stakes run high.

On the other hand the FDA is a bureaucracy with allegiances and political agendas, not because they are necessarily evil but because this is a given for group behavior. They are shaped by society and moved by mass public opinion. They also make mistakes and if some of the lifesaving drugs we have today would have needed FDA approval masses would be dying while wars were fought that have little to do with how well something works.

Do I think most people or their doctors have enough medical training to make an informed choice about stem cells? No…but I am not sure the FDA is in a position to make this choice for the best interests of the people and I would welcome some of the transparency they have promised.

Would I consider not having FDA approval for a therapy before using it on myself or family? I would not consider a banned or illegal substance but I would have non FDA sanctioned treatment or off label use of pharmaceuticals. It has in the past improved my quality and likely my length of life. I would not consider a choice like this lightly. The risks need to be weighed against the benefits and I would have to know and trust the doctor involved whether in this country or somewhere else on the globe.

Your Own Stem Cells Cultured On Contact Lens Can Restore Sight

By Amy Price PhD

“The procedure is totally simple and cheap,” reports UNSW’s Dr Nick Di Girolamo (lead author of research study), “Unlike other techniques, it requires no foreign human or animal products, only the patient’s own serum, and is completely non-invasive. This preliminary trial was conducted on three people, two with extensive corneal damage resulting from multiple surgeries to remove ocular melanomas, and one with the genetic eye condition aniridia. The patient with aniridia had damage in both eyes so stem cells were taken from the conjunctiva area. Because stem cells have not yet differentiated into specific cells they could grow into the cells that were needed. Each patient’s sight improved significantly after only a couple of months

Here is how it works. Less than a millimeter of tissue is taken from the ocular surface of the patients own eye. It takes a couple of hours to prepare the eye and put the contact lens with the baby cells in place and the patient goes home. The stem cells are cultured on a post surgical contact lens which is then placed onto the damaged cornea for 10 days, during which time the cells are able to re-colonise and heal the damaged eye surface. Apparently it took some experimentation to find a lens that could be successfully used as a scaffold for the cells.

The scientists on this research project see this therapy as a simple way to restore sight for eyes damaged by scarring, chemotherapy and a range of other disorders. They suggest that all is needed is a simple lab and qualified medical personnel putting it within reach of even third world countries

Di Girolamo, Nick; Bosch, Martina; Zamora, Katherine; Coroneo, Minas T.; Wakefield, Denis; Watson, Stephanie L. A Contact Lens-Based Technique for Expansion and Transplantation of Autologous Epithelial Progenitors for Ocular Surface Reconstruction. Transplantation, 2009; 87 (10): 1571 DOI: 10.1097/TP.0b013e3181a4bbf2

Justice-for-All? Amy Price PhD

Illusory statements and human error can set context that overthrows justice. In my life I have seen the guilty walk and the innocent executed based on what passes for science. Probability and statistics are used as weapons promoting authority over individuals unlearned in the field with little regard for the human carnage and heartbreak that follows.
Want to see the power of optical illusions? They are not as powerful as those that can be created by illusory context. Illusions are the gap between perception and processing, they operate in all senses and we are all susceptible
I recently enjoyed a forensics experiment where we were given a cursory fingerprinting class and then were given prints to compare for accuracy. There is a commonly held 16 points of accuracy that until recently was used to determine probability...plenty of room for error, even though Sir Francis Galton says mathematically the chances of identical fingerprints are 60 billion +.
I was interested in the case of a Scottish police officer who because of mistaken identity, lost her job, reputation and was driven to near bankruptcy because her accusers needed to be right more that they cared about justice. The officer later settled for 1.75 million pounds without the agency admitting guilt. I shudder to think how little she would have recovered for personal use after all the 3 ds (denial,delay and) were exercised. In fact those that brought faulty evidence were later exonerated by the department. Of course a 273 page document explaining how to do it better was produced but I doubt the officer gets royalties...
Dr Itiel Dror shared in an interview with the BBC how he engaged forensic specialists in a study where he linked context with perception during fingerprint analysis. There was a large error rate. The video and study is worth viewing. He shows how the stage can be set for seasoned professionals to make errors
In another case a Lawyer was held in Oregon as a terror suspect, his life was derailed and finally with the words "regrettably there was an error" he was released. I doubt that fixed much for him or bought him back time that was stolen in the prime of his life. He will likely be remembered as the 'Terror Suspect" rather than for other contributions he makes.
In the experiment most of us correctly identified these prints as not matching his. What went wrong? Try it for yourself

What is the take home message? Before you render judgement or accusation really listen with a mind to hear. Your 'facts' may be clouded by context and false perception. At any rate we can choose a blame free course where together we fix the things that are broken and produce unity instead of destruction

Parkinson's Disease Stem Cell Sequel

By Amy Price PhD

I found an interesting addition to the Parkinson's post's in the form of an article from Nature. Many thanks from helpful individuals at the Open University in the UK for passing this on.

In the article in Nature Suchowersky O. Transplantation therapy for Parkinson disease: the good, the bad and the enigmatic. Nature clinical practice. Neurology. 2008 Sep;4(9):465
Parkinson disease (PD) affects an estimated 1 million cases in North America . Motor symptoms in PD initially
respond well to dopaminergic replacement medications, but because PD progresses the drugs gradually lose effectiveness after about 10 years resulting in gait dysfunction and complications such as dyskinesias
PD is not just a disorder of the dopaminergic system but involves other neurotransmitter systems which inform autonomic dysfunction, mood disorders, fatigue, pain, sleep disorders and cognitive function. Dopaminergic cell replacement, even if successful is thought capable of treating only motor symptoms.
Over 20 years ago, transplantation of fetal ventral mesencephalic cells into the putamen was
performed on a small sample of participants with reportedly good results. Regrettably further studies with larger participant pools failed to confirm the initial reports (Freed CR et al. [2001] N Engl
J Med 344: 710–719). PET and pathological analyses revealed adequate survival of grafted
neurons, and there was untreatable runaway dyskenesia. However clinical benefit was seen in
a small subset of patients, 16 years on autopsy results are available Mendez et al. showed survival of
grafts without PD pathology for 14 years in five patients (Mendez I et al. [2008] Nat Med14: 507–509). Another patient showed good clinical improvement l 5 years plus, before gradual worsening of motor function and development of gait and balance problems (Kordower JH et al. [2008] Nat Med 14: 504–506). Autopsy results from this patient 14 years after transplantation showed great graft survival but grafted neurons had pathological
changes typical of PD, including Lewy bodies and activated microglia (cell scavengers) were seen in large numbers
Liet al. reported similar graft pathology in three patients up to 16 years after transplantation (Li JY et al. [2008] Nat Med 14: 501–503). These results indicate that for stem cell therapy to be effectual long term in D research needs to be initiated to investigate the spread to youn grafted neurons and determine strategies to resolve this issue. I would hope that advancement in the area of Adult Stem Cell research will make this possible in the near future.

I am finding the stem cell story is not so new. I did hear about a very young women stricken with metasticized spinal cancer who was treated at Sloan Kettering with grown out adult stem cells taken from her own bone marrow over fifteen years ago. She is now a successful professional with no trace of malignancy in her body. I also remember twenty five years ago in Canada I knew three terminal patients who underwent adjustments to the bone marrow transplant protocol that involved growing out their own bone marrow cells. One person enjoyed a year free from blood cancer and then relapsed but the other two lived. It is strange that when I go to Pub Med , Google Scholar or even the University library there is no trace of this research performed for "humanitarian reasons"

There is also a lot of interest in the London Project where stem cell trials are close to human trials for those with macular degeneration. Pfizer is quoted as expected to announce backing of stem cell therapy, apparently with joint labs in Cambridge Mass and Cambridge UK but on the Pfizer site I didn't see this in place.

Individuals are reporting encouraging success for adult stem cell treatment where they are thier own donors particularly for orthopedic and cardiac applications. These treatments are largely privately funded. It would be great to see this in the mainstream covered by insurance and available for people regardless of income levels

A Pill For Memory? Piracetam Revisited

By Amy Price PhD

One significant problem in traumatic brain injury is that secondary cell death occurs when the injured cells block the path for the other cells to get oxygen. One product that is used extensively in other countries but not the USA is Piracetam. It is interesting that research in pub med is showing promise for efficacy in human trials. There have been rat, rabbit, and fruit fly trials available for years but there is a lot that can differ between these and seeing actual human benefit.

I used this product to good effect many years ago without side effects and am encouraged to see studies supporting its effectiveness. The alternatives available to many people with TBI as far as psychotropic meds to restore some measure of function are concerned can sometimes have unexpected reactions or be of no effect.

Piracetam has been shown to alter the physical properties of the plasma membrane by increasing its fluidity and by protecting the cell against hypoxia. It increases red cell deformability and normalizes aggregation of hyperactive platelets according to Winnicka K, Tomasiak M, Bielawska A (2005) They are saying treatment with piracetam improves learning, memory, brain metabolism, and capacity by the interaction of this molecule with the membrane phospholipids to restore membrane fluidity . The draft below is from smart publications

The positive therapeutic effects of piracetam on cognitive (memory, attention, executive functions) and motor (coordination) functions as well as the speed of cognitive and motor performance were demonstrated in a study done by Zh Nevrol Psikhiatr Im S S Korsakova. 2008 for adolescents who sustained TBI's.

Its efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia, and sickle cell anemia according to Winblad B (2005).

The results of a meta-analysis Waegemans T, Wilsher CR, Danniau A, Ferris SH, Kurz A, Winblad B. (2002) demonstrate a difference between those individuals treated with piracetam and those given placebo, both as significant odds ratio and as a favourable number needed to treat. While there may be problems in meta-analyses and the interpretation of the statistical results, the results of this analysis provide compelling evidence for the global efficacy of piracetam in a diverse group of older subjects with cognitive impairment.

This post does not in any way constitute any medical advice or recommendation. These posts are educational only to share with others some of the direction research is taking. Any medical information gained online should be supported and endorsed by your own doctor.

References:

[The consequences of closed traumatic brain injury and piracetam efficacy in their treatment in adolescents]
Zavadenko NN, Guzilova LS.
Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(3):43-8. Russian.
PMID: 18427539 [PubMed - indexed for MEDLINE]
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Piracetam--an old drug with novel properties?
Winnicka K, Tomasiak M, Bielawska A.
Acta Pol Pharm. 2005 Sep-Oct;62(5):405-9. Review.
PMID: 16459490 [PubMed - indexed for MEDLINE]
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Piracetam: a review of pharmacological properties and clinical uses.
Winblad B.
CNS Drug Rev. 2005 Summer;11(2):169-82. Review.
PMID: 16007238 [PubMed - indexed for MEDLINE]
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Clinical efficacy of piracetam in cognitive impairment: a meta-analysis.
Waegemans T, Wilsher CR, Danniau A, Ferris SH, Kurz A, Winblad B.
Dement Geriatr Cogn Disord. 2002;13(4):217-24.
PMID: 12006732 [PubMed - indexed for MEDLINE]
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